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Breaking rules: the complex relationship between DNA methylation and X-chromosome inactivation in the human placenta

March, 2025. Biology of Sex Differences 16, Article #18. In this study led by Amy Inkster, we examine DNA methylation in the human placenta on the X chromosome in over 350 placental samples. We found that the placenta has unique DNA methylation patterns on the inactive X chromosome (the second X chromosome in females, which is typically…

Magda’s paper accepted

Congrats to Magda Price (PhD student) on her paper accepted to Epigenetics: Price EM, Cotton AM, Peñaherrera MS,  McFadden DE, Kobor MS, Robinson WP.  Different measures of “genome-wide” DNA methylation exhibit unique properties in placental and somatic tissues. Magda compared various approaches used in the literature as “genome-wide” methylation, and concluded that “L1, Alu and CpG…