Publications

Selected publications
2017
2016

Placental telomere length decline with gestational age differs by sex and TERT, DNMT1, and DNMT3A DNA methylation. Wilson SL, Liu Y, Robinson WP. Placenta. 2016 Dec;48:26-33.

Characterizing the hypomethylated DNA methylation profile of nucleated red blood cells from cord blood. de Goede OM, Lavoie PM, Robinson WP. Epigenomics. 2016 Nov;8(11):1481-1494

Cell-Free Placental DNA in Maternal Plasma in Relation to Placental Health and Function. Manokhina I, Singh TK, Robinson WP. Fetal Diagn Ther. 2016 Aug 26

Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma. Becker-Santos DD, Thu KL, English JC, Pikor LA, Martinez VD, Zhang M, Vucic EA, Luk MT, Carraro A, Korbelik J, Piga D, Lhomme NM, Tsay MJ, Yee J, MacAulay CE, Lam S, Lockwood WW, Robinson WP, Jurisica I, Lam WL.  J Pathol. 2016 Oct;240(2):161-72

Profiling placental and fetal DNA methylation in human neural tube defects. Price EM, Peñaherrera MS, Portales-Casamar E, Pavlidis P, Van Allen MI, McFadden DE, Robinson WP. Epigenetics Chromatin. 2016 Feb 16;9:6.

Pervasive polymorphic imprinted methylation in the human placenta. Hanna CW, Peñaherrera MS, Saadeh H, Andrews S, McFadden DE, Kelsey G, Robinson WP. Genome Res. 2016 Jun;26(6):756-67

2015

Placental DNA methylation at term reflects maternal serum levels of INHA and FN1, but not PAPPA, early in pregnancy. Wilson SL, Blair JD, Hogg K, Langlois S, von Dadelszen P, Robinson WP. BMC Med Genet. 2015 Dec 11;16:111

Noninvasive nucleic acid-based approaches to monitor placental health and predict pregnancy-related complications. Manokhina I, Wilson SL, Robinson WP. Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S197-206. doi: 10.1016/j.ajog.2015.07.010. Review

Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells.  de Goede OM, Razzaghian HR, Price EM, Jones MJ, Kobor MS, Robinson WP, Lavoie PM. Clin Epigenetics. 2015 Sep 11;7(1):95.

ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion. Aghababaei M, Hogg K, Perdu S, Robinson WP, Beristain AG. Cell Death Differ. 2015 Dec;22(12):1970-84.

The human placental methylome. Robinson WP, Price EM. Cold Spring Harb Perspect Med. 2015 Feb 26;5(5):a023044. doi: 10.1101/cshperspect.a023044. Review.

Genome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity. Hu Y, Blair JD, Yuen RK, Robinson WP, von Dadelszen P. Mol Hum Reprod. 2015 May;21(5):452-65.

Functional consequences of copy number variants in miscarriage Wen J, Hanna CW, Martell S, Leung PC, Lewis SM, Robinson WP, Stephenson MD, Rajcan-Separovic E. Mol Cytogenet. 2015 Jan 31;8:6

Recurrent triploidy due to a failure to complete maternal meiosis II: whole-exome sequencing reveals candidate variants. Filges I, Manokhina I, Peñaherrera MS, McFadden DE, Louie K, Nosova E, Friedman JM, Robinson WP. Mol Hum Reprod. 2015 Apr;21(4):339-46.

2014

Quantification of cell-free DNA in normal and complicated pregnancies: overcoming biological and technical issues. Manokhina I, Singh TK, Peñaherrera MS, Robinson WP. PLoS One. 2014 Jul 2;9(7):e101500.

A cryptic familial rearrangement of 11p15.5, involving both imprinting centers, in a family with a history of short stature. Brown LA, Rupps R, Peñaherrera MS, Robinson WP, Patel MS, Eydoux P, Boerkoel CF. Am J Med Genet A. 2014 Jun;164A(6):1587-94.

Overlapping DNA methylation profile between placentas with trisomy 16 and early-onset preeclampsia. Blair JD, Langlois S, McFadden DE, Robinson WP. Placenta. 2014 Mar;35(3):216-22.

Improved reporting of DNA methylation data derived from studies of the human placenta. Hogg K, Price EM, Robinson WPEpigenetics. 2014 Mar;9(3):333-7.

2013

Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia. Blair JD, Yuen RK, Lim BK, McFadden DE, von Dadelszen P, Robinson WP. Mol Hum Reprod. 2013 Oct;19(10):697-708.

DNA methylation profiling of placental villi from karyotypically normal miscarriage and recurrent miscarriage. Hanna CW, McFadden DE, Robinson WPAm J Pathol. 2013 Jun;182(6):2276-84

Early onset pre-eclampsia is associated with altered DNA methylation of cortisol-signalling and steroidogenic genes in the placenta. Hogg K, Blair JD, McFadden DE, von Dadelszen P, Robinson WPPLoS One. 2013 May 7;8(5):e62969.

The human placenta methylome. Schroeder DI, Blair JD, Lott P, Yu HO, Hong D, Crary F, Ashwood P, Walker C, Korf I,Robinson WP, LaSalle JM. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6037-42

Maternal NLRP7 and C6orf221 variants are not a common risk factor for androgenetic moles, triploidy and recurrent miscarriage. Manokhina I, Hanna CW, Stephenson MD, McFadden DE, Robinson WPMol Hum Reprod. 2013 Apr 4.

Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array. Price EM, Cotton AM, Lam LL, Farré P, Emberly E, Brown CJ, Robinson WP, Kobor MS. Epigenetics Chromatin. 2013 Mar 3;6(1):4.

Hypomethylation of the LEP gene in placenta and elevated maternal leptin concentration in early onset pre-eclampsia. Hogg K, Blair JD, von Dadelszen P, Robinson WP. Mol Cell Endocrinol. 2013 Mar 10;367(1-2):64-73.

Hypoxia alters the epigenetic profile in cultured human placental trophoblasts.Yuen RK, Chen B, Blair JD, Robinson WP, Nelson DM. Epigenetics. 2013 Jan 11;8(2).

2012

Prenatal and perinatal environmental influences on the human fetal and placental epigenome. Hogg K, Price EM, Hanna CW, Robinson WP. Clin Pharmacol Ther. 2012 Dec;92(6):716-26.

Different measures of “genome-wide” DNA methylation exhibit unique properties in placental and somatic tissues. Price EM, Cotton AM, Peñaherrera MS, McFadden DE, Kobor MS, Robinson W. Epigenetics. 2012 Jun 1;7(6):652-63.

Patterns of placental development evaluated by X chromosome inactivation profiling provide a basis to evaluate the origin of epigenetic variation. Peñaherrera MS, Jiang R, Avila L, Yuen RK, Brown CJ, Robinson WP. Hum Reprod. 2012 Mar 19

DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF. Hanna CW, Bloom MS, Robinson WP, Kim D, Parsons PJ, Vom Saal FS, Taylor JA, Steuerwald AJ, Fujimoto VY. Hum Reprod. 2012 Feb 29

Absence of SYCP3 mutations in women with recurrent miscarriage with at least one trisomic miscarriage. Hanna CW, Blair JD, Stephenson MD, Robinson WP. Reprod Biomed Online. 2012 Feb;24(2):251-3

2011

Are we ready for DNA methylation-based prenatal testing? Yuen RK, Manokhina I, Robinson WP. Epigenomics. 2011 Aug;3(4):387-90.

Evidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors. Novakovic B, Yuen RK, Gordon L, Penaherrera MS, Sharkey A, Moffett A, Craig JM, Robinson WP, Saffery R. BMC Genomics. 2011 Oct 28;12:529.

Genome-wide mapping of imprinted differentially methylated regions by DNA methylation profiling of human placentas from triploidies. Yuen RK, Jiang R, Peñaherrera MS, McFadden DE, Robinson WP. Epigenetics Chromatin. 2011 Jul 13;4(1):10.

Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation. Cotton AM, Lam L, Affleck JG, Wilson IM, Peñaherrera MS, McFadden DE, Kobor MS, Lam WL, Robinson WP, Brown CJ. Hum Genet. 2011 Aug;130(2):187-201. Epub 2011 May 20.

Extensive epigenetic reprogramming in human somatic tissues between fetus and adult. Yuen RK, Neumann SM, Fok AK, Peñaherrera MS, McFadden DE, Robinson WP, Kobor MS. Epigenetics Chromatin. 2011 May 5;4:7.

Review: A high capacity of the human placenta for genetic and epigenetic variation: implications for assessing pregnancy outcome. Yuen RK, Robinson WP. Placenta. 2011 Mar;32 Suppl 2:S136-41. Epub 2011 Feb 1. Review.

2010

Evaluating DNA methylation and gene expression variability in the human term placenta. Avila L, Yuen RK, Diego-Alvarez D, Peñaherrera MS, Jiang R, Robinson WP. Placenta. 2010 Dec;31(12):1070-7. Epub 2010 Oct 14

DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia. Yuen RK, Peñaherrera MS, von Dadelszen P, McFadden DE, Robinson WP. Eur J Hum Genet. 2010  Sep;18(9):1006-12.  [Epub ahead of print May 5.]

Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage.Hanna CW, Bretherick KL, Liu CC, Stephenson MD, Robinson WP. Hum Reprod. 2010 Oct;25(10):2664-71.

Methylation profiling in individuals with Russell-Silver syndrome. Peñaherrera MS, Weindler S, Van Allen MI, Yong SL, Metzger DL, McGillivray B, Boerkoel C, Langlois S, Robinson WP. Am J Med Genet A. 2010 Feb;152A(2):347-55.

Decreased placental methylation at the H19/IGF2 imprinting control region is associated with normotensive intrauterine growth restriction but not preeclampsia. Bourque DK, Avila L, Peñaherrera M, von Dadelszen P, Robinson WP. Placenta. 2010 Mar;31(3):197-202. Epub 2010 Jan 8.

Assessing the role of placental trisomy in preeclampsia and intrauterine growth restriction. Robinson WP, Peñaherrera MS, Jiang R, Avila L, Sloan J, McFadden DE, Langlois S, von Dadelszen P. Prenat Diagn. 2010 Jan;30(1):1-8.

2009

Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes. Yuen RK, Avila L, Peñaherrera MS, von Dadelszen P, Lefebvre L, Kobor MS, Robinson WP. PLoS One. 2009 Oct 19;4(10):e7389.

Inactive X chromosome-specific reduction in placental DNA methylation. Cotton AM, Avila L, Penaherrera MS, Affleck JG, Robinson WP, Brown CJ. Hum Mol Genet. 2009 Oct 1;18(19):3544-52. Epub 2009 Jul 7.

Fertility and aging: do reproductive-aged Canadian women know what they need to know? Bretherick KL, Fairbrother N, Avila L, Harbord SH, Robinson WP. Fertil Steril. 2009 Mar 16. [Epub ahead of print]

Telomere length and reproductive aging. Hanna CW, Bretherick KL, Gair JL, Fluker MR, Stephenson MD, Robinson WP. Hum Reprod. 2009 May;24(5):1206-11. Epub 2009 Feb 6.

2008 and earlier

 

Estrogen receptor alpha gene polymorphisms are associated with idiopathic premature ovarian failure. Bretherick KL, Hanna CW, Currie LM, Fluker MR, Hammond GL, Robinson WP. Fertil Steril. 2008 Feb;89(2):318-24.

Robinson WP, Slee J, Smith N, Murch A, Watson SK, Lam WL, McFadden DE. Placental mesenchymal dysplasia associated with fetal overgrowth and mosaic deletion of the maternal copy of 11p15.5.

Bretherick KL, Metzger DL, Chanoine JP, Panagiotopoulos C, Watson SK, Lam WL, Fluker MR, Brown CJ, Robinson WP. Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure. Am J Med Genet A. 2007 May 1;143(9):945-51

Robinson WP, McGillivray B, Friedman JM. Pregnancy and postnatal outcome of mosaic isochromosome 20q. Prenat Diagn. 2006 Dec 27;27(2):143-145

Hirschfeld AF, Jiang R, Robinson WP, McFadden DE, Turvey SE. Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage. Hum Reprod. 2007 Feb;22(2):440-443. Epub 2006 Sep 18.

McFadden DE, Robinson WP. Phenotype of triploid embryos. J Med Genet. 2006 Jul;43(7):609-12. Epub 2005 Oct 19.

Robinson WP, Lauzon JL, Innes AM, Lim K, Arsovska S, McFadden DE. Origin and outcome of pregnancies affected by androgenetic/biparental chimerism. Hum Reprod. 2006 Dec 21;

Langlois S, Yong PJ, Yong SL, Barrett I, Kalousek DK, Miny P, Exeler R, Morris K, Robinson WP. Postnatal follow-up of prenatally diagnosed trisomy 16 mosaicism. Prenat Diagn. 2006 Jun;26(6):548-58. Abstract

Bretherick K, Gair J, Robinson WP. The association of skewed X chromosome inactivation with aneuploidy in humans. Cytogenet Genome Res. 2005;111(3-4):260-5. Review. Abstract

Gair JL, Arbour L, Rupps R, Jiang R, Bruyere H, Robinson WP. Recurrent trisomy 21: four cases in three generations. Clin Genet. 2005 Nov;68(5):430-5. Abstract

Bretherick KL, Fluker MR, Robinson WP. FMR1 repeat sizes in the gray zone and high end of the normal range are associated with premature ovarian failure. Hum Genet. 2005 Aug;117(4):376-82. Epub 2005 Jun 2.Abstract

Kaiser-Rogers KA, McFadden DE, Livasy CA, Dansereau J, Jiang R, Knops JF, Lefebvre L, Rao KW, Robinson WP (2005) Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia. J  Med Genet. 2005 May 20; Abstract

Robinson WP, McGillivray B, Lewis ME, Arbour L, Barrett I, Kalousek DK (2005) Prenatally detected trisomy 20 mosaicism.Prenat Diagn. 2005 Mar;25(3):239-44. Abstract

Hatakeyama C, Anderson CL, Beever CL, Penaherrera MS, Brown CJ, Robinson WP. (2004) The dynamics of X-inactivation skewing as women age. Clin Genet. 2004 Oct;66(4):327-32. Abstract

Tang SS, Gao H, Robinson WP, Ho Yuen B, Ma S. (2004) An association between sex chromosomal aneuploidy in sperm and an abortus with 45,X of paternal origin: possible transmission of chromosomal abnormalities through ICSI. Hum Reprod. 19(1):147-51. Abstract

Peñaherrera MS, Ma S, Ho YB, Brown CJ, Robinson WP (2003) X-chromosome inactivation (XCI) patterns in placental tissues of a paternally derived bal t(X;20) case. Am J Med Genet 118A(1):29-34 Abstract

Yong PJ, Barrett IJ, Kalousek DK and Robinson WP (2003) Prenatal diagnosis and pathogenesis of trisomy 16 mosaicism. J Med Genet 40(3):175-82. (Abstract)

Beever CL, Stephenson MD, Penaherrera MS, Jiang RH, Kalousek DK, Hayden M, Field L, Brown CJ, Robinson WP (2003) Skewed X chromosome inactivation is associated with trisomy in women ascertained on recurrent spontaneous abortion or chromosomally abnormal pregnancies. Am J Hum Genet (Abstract)

Robinson WP,Barrett IJ, Kuchinka B,  Peñaherrera MS, Bruyere H, Best R, Pediera D, MCFadden DE, Langlois SL, Kalousek DK. (2002) Origin of amnion and implications for evaluation of the fetal genotype in cases of mosaicism. Prenat Diag 22:1078-87. (Abstract)

McFadden DE, Jiang RH, Langlois S, Robinson WP (2002) Dispermy – origin of diandric triploidy. Hum Reprod 17:3037-38 (Abstract)

Yong PJ, Marion SA, Kalousek DK, Robinson WP (2002) Evidence for imprinting on chromosome 16: the effect of uniparental disomy on the outcome of mosaic trisomy 16 pregnancies. Am J Med Genet 112(2):123-32 (Abstract)

Robinson, WP, Beever C, Brown CJ, Stephenson MD (2001) Skewed X-inactivation in recurrent spontaneous abortion (2001) Seminars in Reproductive Medicine 19:175-182 (Abstract)

Lam R; Ma, S; Robinson WP; Theresa Chan T; Basil Ho Yuen, BH (2001) Cytogenetic Investigation of Fetuses and Infants Derived from Intracytoplasmic Sperm Injection.Fertility and Sterility 76(6):1272-5. (Abstract)

Robinson WP, McFadden DE, Stephenson, MS (2001) Origin of Recurrent Aneuploidy Am J Hum Genet 69:1245-54 (Abstract)

Bruyère H., Rupps R, Kuchinka B, Friedman JM, Robinson WP (2000) Recurrent trisomy 21 in a couple with a child presenting trisomy 21 mosaicism and maternal uniparental disomy for chromosome 21 in the euploid cell line. Am J Med Genet Sep 4;94(1):35-41. (Abstract)

MS Peñaherrera, IJ Barrett , CJ Brown, S Langlois, S-L. Yong, S. Lewis, H. Bruyère, P. Howard-Peebles, D.K Kalousek, W.P. Robinson (2000) An association between skewed X-chromosome inactivation in diploid fetal tissues and abnormal outcome in mosaic trisomies predominantly confined to the placenta. Clin Genet 58(6):436-46. (Abstract)

Robinson WP (2000) Mechanisms leading to uniparental disomy and their clinical consequences. Bioessays 22:452-459(Abstract)

Brown CJ, Robinson WP (2000) The causes and consequences of random and non-random X chromosome inactivation in humans. Clin Genet. 2000 Nov;58(5):353-63. (Abstract)

Robinson WP, Bernasconi F, Lau A, McFadden DE (1999) Origin of trisomy: the effect of ascertainment. Am J Med Genet 84:34-42 (Abstract)

Robinson WP, Kuchinka BD, Bernasconi F, Petersen MB, Schulze A, Brøndum-Nielsen K, Christian SL, et al. (1998) Maternal meiosis I nondisjunction of chromosome 15: dependence of the maternal age effect on level of recombination. Hum Mol Genet 7:1011-1020 (Abstract)

Robinson WP, Barrett IJ , Bernard L, Bernasconi F, Wilson RD, Best R, Howard-Peebles PN, Langlois S, Kalousek DK. (1997) A meiotic origin of trisomy in confined placental mosaicism is correlated with presence of fetal uniparental disomy, high levels of trisomy in trophoblast and increased risk of fetal IUGR. Am J Hum Genet 60:917-927 (Abstract)

Lau AW, Brown CJ, Penaherrera M, Langlois S, Kalousek DK, Robinson WP (1997) Skewed X-chromosome inactivation is common in fetuses or newborns associated with confined placental mosaicism. Am J Hum Genet 61:1353-61 (Abstract)