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Breaking rules: the complex relationship between DNA methylation and X-chromosome inactivation in the human placenta

March, 2025. Biology of Sex Differences 16, Article #18. In this study led by Amy Inkster, we examine DNA methylation in the human placenta on the X chromosome in over 350 placental samples. We found that the placenta has unique DNA methylation patterns on the inactive X chromosome (the second X chromosome in females, which is typically…

Preparing for IFPA

In September 2016 the International Federation of Placenta Assocations (IFPA) meeting was in lovely Portland, Oregon. To prepare for the meeting, the lab (in part) plus collaborator Alex B. hit the mountain trails in Central Oregon. What could be more inspiring than breathing in the mountain air, listening to some folk music in nearby Sisters and enjoying dinners in…

Lab Goes Kayaking! May 2016

Great time kayaking out in False Creek in late Spring 2016! Poured rain and a bit cold at the end, but nothing the pub couldn’t cure after. The event celebrated the graduation of Magda P. (PhD, studying DNAm and Neural Tube Defects)and Olivia de G. (MSc studying DNAm in cord blood cells from preterm and term births…

John’s publications

John’s Master degree work on DNA methylation changes in preeclampsia has come out in two publications. The first study demonstrates how many changes in DNA methylation there are in placentas with preeclampsia—Thousands! So many its hard to know what to say except –wow! How does the placenta support the baby at all when so much…

Transitions

First of all congratulations to Courtney Hanna who completed her PhD late last spring and moved on to an exciting postdoctoral fellowship at the Babraham Institute in Cambridge, England. Also to John Blair who completed his Masters last summer and moved on to my former Alma Mater (UC Berkeley) and is now enjoying all the…